Made to measure – keeping Rho kinase at a distance

Made to measure – keeping Rho kinase at a distance

The Rho-associated coiled-coil containing kinases (ROCK) were first identified as effectors of the small GTPase RhoA, hence their nomenclature. Since their discovery, two decades ago, scientists have sought to unravel the structure, regulation, and function of these essential kinases. During that time, a consensus model has formed, in which ROCK activity is regulated via both Rho-dependent and ...

Revision of a fuzzy distance measure

Limbs Made to Measure

This year marks the 150th anniversary of the birth of D’Arcy Thompson, the British biologist, classicist, and all round polymath (For more information on D’Arcy Thompson see www. darcythompson.org). Like many, he was fascinated by the appearance and structure of living matter, and in his influential book, On Growth and Form [1], he set out to describe and explain the principles of morphogenesis...

Made to measure?

324 British Journal of General Practice, June 2013 My next patient walks in confidently wearing a big smile. All the training I’ve done in non-verbal communication kicks in and I suspect that his depression is starting to get better. He hands me a PHQ-9 with a flourish which confirms my initial impressions. I’m usually sceptical of these scoring tools, but this is no ordinary PHQ-9, this a luxu...

Some properties of a new fuzzy distance measure